3-oxoacyl-ACP reductase from Schistosoma japonicum: integrated in silico-in vitro strategy for discovering antischistosomal lead compounds.

BACKGROUND: Schistosomiasis is a disease caused by parasitic worms and more than 200 million people are infected worldwide.The emergence of resistance to the most commonly used drug, praziquantel (PZQ), makes the development of novel drugs an urgent task.3-oxoacyl-ACP reductase (OAR), a key enzyme involved in the fatty acid synthesis pathway, has b

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A Herpes Simplex Virus Type 2 Deleted for Glycoprotein D Enables Dendritic Cells to Activate CD4+ and CD8+ T Cells

Herpes simplex virus type 2 (HSV-2) is highly prevalent in the human population producing significant morbidity, mainly because of the generation of genital ulcers and neonatal encephalitis.Additionally, HSV-2 infection significantly increases the susceptibility of the host to acquire HIV and promotes the shedding of the latter in the coinfected.De

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The Serological Prevalence of Rabies Virus-Neutralizing Antibodies in the Bat Population on the Caribbean Island of Trinidad

Rabies virus (RABV) is the only lyssavirus known to be present within the Caribbean.The island of Trinidad, is richly diverse in chiropteran fauna and endemic for bat-transmitted rabies with low RABV isolation rates observed in this population.We aimed to determine the seroprevalence of rabies virus neutralizing antibodies (RVNA) in light of spatio

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